To get to Manta by plane, the best way to do it is flying to Manta Int Airport with a stop in Quito (Mariscal Sucre Airport), most cities flight to Quito and from there you can get to Manta in one of the daily flights that Tame, Avianca or LAN offer.
The other way to do it is flying to Guayaquil (Joaquin de Olmedo Airport) and then by land a 2 hour trip to Manta that can be made by bus, taxi, Uber or renting a car.
Eloy Alfaro International Airport (City of Manta)
Airports with connection: (From closest to furthest)
José Joaquín de Olmedo Airport (Guayaquil)
2-3 hour drive to Manta by car, bus or taxi/uber.
Recommended airlines: Avianca, LAN.
Mariscal Sucre International Airport (Quito)
45 minutes flight to Manta or 6 hours by car or bus. Recommended airlines: Avianca, LAN.